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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Bret Saberhagen# | 581 | 1984-1998 | |
| 2 | Ron Robinson# | 547 | 1984-1998 | |
| 3 | Jose DeLeon# | 539 | 1983-1997 | |
| 4 | Bill Gullickson | 526 | 1979-1996 | |
| 5 | Scott Sanderson | 479 | 1978-1992 | |
| 6 | John Candelaria | 464 | 1976-1990 | |
| 6 | Jamie Moyer# | 464 | 1987-1998 | |
| 8 | Bruce Hurst | 442 | 1982-1994 | |
| 9 | Dennis Eckersley | 438 | 1976-1993 | |
| 10 | Jimmy Key# | 433 | 1984-1997 | |
| 11 | Orel Hershiser# | 431 | 1983-1996 | |
| 12 | Scott Bankhead# | 424 | 1986-1998 | |
| 12 | Teddy Higuera# | 424 | 1985-1998 | |
| 14 | Jose Rijo# | 423 | 1984-1998 | |
| 15 | Bob Sebra# | 417 | 1985-1998 | |
| 16 | Marty Bystrom# | 413 | 1980-1998 | |
| 17 | John Fulgham | 403 | 1979-1994 | |
| 18 | Melido Perez# | 396 | 1987-1998 | |
| 19 | Mike Scott | 388 | 1979-1992 | |
| 20 | John Smiley# | 386 | 1986-1998 | |
| 21 | Frank Viola# | 372 | 1982-1994 | |
| 22 | Mark Langston# | 371 | 1984-1997 | |
| 23 | Rick Reed# | 369 | 1988-1998 | |
| 24 | Scott Garrelts# | 365 | 1982-1998 | |
| 25 | Kelly Downs# | 364 | 1986-1998 | |
| 26 | Dwight Gooden# | 363 | 1984-1998 | |
| 27 | Doug Drabek# | 352 | 1987-1998 | |
| 28 | Rick Aguilera# | 341 | 1985-1998 | |
| 28 | Vida Blue* | 341 | 1976-1990 | |
| 28 | Kevin Gross# | 341 | 1983-1997 | |
| 31 | Atlee Hammaker | 340 | 1981-1991 | |
| 32 | Andy Benes# | 338 | 1989-1998 | |
| 32 | John Burkett# | 338 | 1987-1998 | |
| 34 | Randy Johnson# | 337 | 1989-1998 | |
| 35 | Greg Maddux# | 332 | 1986-1998 | |
| 35 | Mike Morgan# | 332 | 1979-1995 | |
| 37 | Bob Ojeda# | 331 | 1982-1998 | |
| 38 | Frank Pastore | 330 | 1979-1993 | |
| 39 | Al Leiter# | 322 | 1988-1998 | |
| 40 | Jack Morris | 321 | 1977-1990 | |
| 41 | Pascual Perez | 320 | 1980-1993 | |
| 42 | Alex Fernandez# | 318 | 1990-1998 | |
| 42 | Curt Schilling# | 318 | 1991-1998 | |
| 44 | Roger Erickson | 316 | 1978-1992 | |
| 45 | Floyd Youmans# | 315 | 1985-1998 | |
| 46 | Erik Hanson# | 312 | 1988-1998 | |
| 47 | Zane Smith# | 308 | 1984-1997 | |
| 48 | LaMarr Hoyt | 303 | 1980-1994 | |
| 49 | Tim Belcher# | 301 | 1987-1997 | |
| 50 | Jay Tibbs# | 296 | 1984-1998 | |
| 51 | Fernando Valenzuela | 295 | 1980-1993 | |
| 52 | Frank Tanana | 293 | 1976-1988 | |
| 52 | John Tudor | 293 | 1979-1992 | |
| 54 | Jon Matlack* | 286 | 1976-1990 | |
| 55 | Jim Abbott# | 285 | 1989-1998 | |
| 55 | Pete Harnisch# | 285 | 1989-1997 | |
| 55 | Gary Serum | 285 | 1978-1988 | |
| 55 | John Smoltz# | 285 | 1988-1998 | |
| 59 | Larry McWilliams | 284 | 1978-1989 | |
| 59 | Juan Nieves# | 284 | 1986-1998 | |
| 59 | Todd Van Poppel# | 284 | 1991-1998 | |
| 62 | Mark Portugal# | 274 | 1985-1998 | |
| 62 | Wally Whitehurst# | 274 | 1989-1998 | |
| 64 | Ramon J. Martinez# | 273 | 1988-1998 | |
| 65 | Ed Correa# | 270 | 1985-1998 | |
| 66 | Mark Fidrych | 269 | 1976-1988 | |
| 66 | Rick Rhoden | 269 | 1976-1992 | |
| 68 | Dennis Martinez | 266 | 1976-1991 | |
| 69 | Charlie Leibrandt | 262 | 1979-1990 | |
| 70 | Mike Parrott | 260 | 1977-1993 | |
| 71 | Bill C. Swift | 259 | 1985-1996 | |
| 72 | Kevin Tapani# | 258 | 1989-1997 | |
| 73 | Silvio Martinez | 256 | 1977-1993 | |
| 74 | Joe Hesketh | 255 | 1984-1993 | |
| 75 | Chris Bosio# | 253 | 1986-1997 | |
| 75 | Jim Clancy | 253 | 1977-1991 | |
| 77 | Jeff Sellers# | 251 | 1986-1995 | |
| 78 | Bob Kipper | 248 | 1985-1994 | |
| 78 | Ben McDonald# | 248 | 1989-1997 | |
| 80 | Marvin Freeman# | 247 | 1986-1998 | |
| 80 | Kirk McCaskill# | 247 | 1985-1995 | |
| 80 | Rod Nichols | 247 | 1988-1996 | |
| 83 | Danny Jackson | 246 | 1983-1996 | |
| 83 | Mike Mussina# | 246 | 1991-1998 | |
| 85 | Bob Shirley | 244 | 1977-1991 | |
| 86 | Eric King# | 242 | 1987-1998 | |
| 87 | John Mitchell# | 237 | 1986-1997 | |
| 88 | J.R. Richard | 234 | 1976-1988 | |
| 89 | David Clyde | 233 | 1976-1990 | |
| 89 | David Wells# | 233 | 1987-1998 | |
| 91 | Roger Clemens# | 232 | 1984-1998 | |
| 92 | Mark Guthrie# | 231 | 1989-1998 | |
| 92 | Chris Haney# | 231 | 1992-1998 | |
| 92 | Pete Schourek# | 231 | 1991-1998 | |
| 95 | Bill Wegman# | 229 | 1985-1997 | |
| 96 | Eric Plunk# | 227 | 1986-1997 | |
| 97 | Mike Harkey# | 226 | 1988-1998 | |
| 97 | Matt Young# | 226 | 1983-1998 | |
| 99 | Pat Zachry | 225 | 1976-1989 | |
| 100 | Joaquin Andujar | 224 | 1977-1987 |
